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Fig. 2 | Epigenetics & Chromatin

Fig. 2

From: Analysis of long-range chromatin contacts, compartments and looping between mouse embryonic stem cells, lens epithelium and lens fibers

Fig. 2

Mapping of chromatin loops and TADs in ES and lens cells. (a) Interaction maps of chromosome 3 generated from ES, lens epithelium and lens fiber cells. Interactions shown are over the span of ~ 160 Mb and are binned at 250 kb resolution. (b) Magnified view of a representative segment of 67–75 Mb on chromosome 3 showing marked differences in chromosome interactions between ESCs and lens cells. Interactions shown are binned at 10 kb resolution. (c) Distribution of loop sizes called in ES, lens epithelium and lens fiber cells, respectively. Dashed lines connect scale ranges to show all data points. (d) Number of TADs called in ES, lens epithelium and lens fiber cells including their median TAD sizes: 145, 135 and 335 kb, respectively. Significance bars denoted with asterisks: p ≤ 0.05, p ≤ 0.01 and p ≤ 0.001 denoted as *, **, *** respectively

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Epigenetics & Chromatin

ISSN: 1756-8935